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Dr. Yu Qiang's interview with Suzhou Daily: My "Tenon and Mortise Date" with the Park

  • Categories:Media
  • Author:Tang Xiaowen
  • Origin:Suzhou Daily
  • Time of issue:2018-08-10
  • Views:0

(Summary description)On August 10, Suzhou Daily featured a story on the "40th anniversary of reform and opening up - my story with the park", which featured Dr. Yu Qiang, the founder and CEO of Centurion, and the Suzhou Industrial Park. A Promise of Tenon and Dovetail".

Dr. Yu Qiang's interview with Suzhou Daily: My "Tenon and Mortise Date" with the Park

(Summary description)On August 10, Suzhou Daily featured a story on the "40th anniversary of reform and opening up - my story with the park", which featured Dr. Yu Qiang, the founder and CEO of Centurion, and the Suzhou Industrial Park. A Promise of Tenon and Dovetail".

  • Categories:Media
  • Author:Tang Xiaowen
  • Origin:Suzhou Daily
  • Time of issue:2018-08-10
  • Views:0

At the beginning of his return to China, he was full of enthusiasm and was a disciple of four walls.

The hometown calls, the body shadow jianghu, don't Pan hut.

I returned to Suzhou, looking for a lab, a house in a painting with good water in the park.

Invite the old people to spend time with us, the morning phi moon night around the fire.

Several years of rotation, several times success or failure, the road is dangerous and many divergent paths.

The pearl will appear only when the dust has settled.

                               --Yu Qiang

 

 

On August 10, Suzhou Daily featured a story on the "40th anniversary of reform and opening up - my story with the park", which featured Dr. Yu Qiang, the founder and CEO of Centurion, and the Suzhou Industrial Park. A Promise of Tenon and Dovetail".

[Specific page presentation and coverage].

 

 

My "Tenon and Mortise Date" with the Park

【Profile】Yu Qiang

Qiang Yu, who studied in the US after graduating from Peking University and received his PhD in organic chemistry from Kansas State University, returned to China in 2010 to start his own business and founded Shengshi TaiTech Biopharmaceutical Technology Co. Over the years, he has led his team to develop a new class 1 hypoglycemic drug that is comparable to the international advanced level, and established a flash-release formulation platform that "melts in the mouth".

When I was a child, I lived in Suzhou with my family for a few years, and I still remember the feeling of running on the stone slabs of the alleys; now that I have settled in Suzhou again and am working on new drug development in Suzhou Industrial Park, I love the same feeling of running on the road of innovation.

During my 18 years in the US, I was involved in drug discovery in the field of chemical small molecules and discovered a lead chemical that could be used to lower blood sugar. I thought, "This is a good idea, China is a big diabetic country, and in our family, except for me, all my family members suffer from diabetes, so I have to continue this research for both public and private reasons. So, I firmly decided to return to China and start my own business.

In 2010, I moved to Suzhou Industrial Park and set up Centurion Biomedical Technologies (Suzhou) Co. In the early stage of the business, the company had a good start: in 2010, we received a start-up fund from the park, and in 2011, we were awarded as one of the park's leading talents in science and technology, and received millions of subsidies for research and development, rent reductions and interest loans. Today, we have received clinical approvals for five of our own drugs, of which Shengliptin, a Class 1.1 hypoglycemic innovation, is about to complete its first clinical phase and is expected to be launched around 2020. Shengliptin not only completely exceeds the technical specifications of similar imported products in the current market, but also does not cause fasting hypoglycaemia when taken orally, which will truly fill the gap in China.

I had actually compared other cities in China before choosing the park, but I was "amazed" by the park's understanding of biopharmaceuticals, their admiration for innovation and willingness to wait. In 2012, our team developed the predecessor of Shengliptin, but its technical specifications were only on par with similar imported products in the market. We came here to innovate, and without R&D results that surpassed the market, we would not be considered a breakthrough, and we were sorry for the support we received from the government at all levels. So, we decided to reverse our original R&D plan until the end of 2016, when a better Shengliptin was finally launched.

In March 2015, the New Drug Founders Club was established in the Park and I was fortunate to be one of the 40-odd founders. "I was fortunate to be one of the more than 40 founders. This is the poem I wrote for the Founders' Club of New Drugs in the Park, "The Promise of Mortise and Tenon". Tenon and mortise are common structural methods used in ancient Chinese architecture, where the projecting tenon and recessed mortise fit together so well that they can be firmly fixed without nails. The biomedical industry in the Park, as I understand it, is also like this, where innovations interact with resources, funding, policies and services to create a symbiotic ecosystem, which is why I am "rooted" here.

"Shengde, innovation, realism, and zeishi", this is my "original intention" with Shengshi Tai Ke. Eight years ago, I lived in a very crowded place and slept on a wooden bed without a mattress; eight years later, the size of the company has doubled five times and more than 80% of the employees have a master's degree. I have witnessed the innovative development of the park, and I am glad to be part of the drive for innovation in the park. Looking ahead, I believe that Centurion will be able to develop more new and good drugs that are affordable to domestic patients here.

And now, I can finally say out loud, "I came to the park to start my own business!"

(Xiaowen Tang/Editorial)

Milestones

Milestones | Shengshi Taike's new generation DPP-4 inhibitor approved for market launch

Today, the official website of the National Medical Products Administration (NMPA) of China announced that Shengshi Taike's independently developed Class 1 innovative drug, saxagliptin phosphate tablets (formerly known as saxagliptin phosphate tablets), has been approved for market in China. This is a new generation of highly selective DPP-4 inhibitor, which is suitable for improving the blood sugar control of adult type 2 diabetes patients. According to the Guidelines for the Prevention and Treatment of Type 2 diabetes in China, the prevalence of diabetes among adults in China has risen to 11.2%, of which more than 90% are type 2 diabetes. In order to meet the huge clinical demand, some new drugs with different mechanisms of action from traditional oral hypoglycemic drugs have emerged in recent years. Dipeptidyl peptidase-4 (DPP-4) inhibitors are one of them. They not only improve hyperglycemia, but also are not easy to induce hypoglycemia and weight gain. They have the characteristics of rapid oral absorption, long half-life, and long-lasting effect, and are known as "smart" hypoglycemic drugs. Currently, they have been recommended by many domestic and foreign guidelines. As a new generation of highly selective DPP-4 inhibitor independently developed by Shengshi Taike, sengliptin has been continuously selected for the national "Major New Drug Development" special projects in the 12th and 13th Five Year Plans. Due to the excellent data demonstrated in the first phase clinical trial of the best product in the market, it was exempted from phase 2 clinical trials and directly entered phase 3 clinical trials, pioneering the "exemption from two to three" clinical trials in the field of this drug. The results of the phase III clinical trial of Sengliptin led by Professor Ji Linong, director of the Endocrinology Department of Peking University People's Hospital and director of Peking University diabetes Center, showed that in the single drug treatment trial of Sengliptin, the reduction values of HbA1c in the 50mg and 100mg dose groups at the end of the 24th week were 1.08% and 1.07% respectively; In the treatment trial of sengliptin combined with metformin, the glycated hemoglobin decreased by 1.23% and 1.17% in the 50mg and 100mg dose groups at the end of the 24th week, respectively. Meanwhile, both sets of experimental data showed that patients with higher blood sugar levels experienced a greater decrease in glycated hemoglobin levels. In addition to its excellent hypoglycemic effect, what is even more commendable is that in the comparison between the 100mg dose group (high-dose group) and the placebo group in the last 28 weeks, the incidence of adverse reactions of sengliptin is similar to that of the placebo group, and its safety further solves the common adverse reactions in marketed products. At present, metformin combined with leptin has become the main treatment scheme in the clinical application of treating type 2 diabetes. According to Sullivan's research report, by 2030, the market size of leptin in China will exceed 30 billion, with broad market prospects. Ding Juping, the co-founder and president of Shengshi Tyco, said: "I am very glad to see the company's self-developed product, Sengliptin Phosphate Tablets, has been approved for listing. This drug will be the best new hypoglycemic drug of its kind with half the effort and twice the treatment effect. I hope it will benefit the majority of diabetes patients in China as soon as possible after it is approved for listing." Dr. Yu Qiang, the founder and CEO of Shengshi Tyco, said: "Sengliptin's successful approval for listing benefits from Suzhou and the park as a fertile land for entrepreneurship and the strong support of many departments. It is also a" promise of gold "to use our innovative drugs to repay the business friendly services in Suzhou Park. At this moment, I would like to use an original poem to bless this new drug for its successful launch." Morimu's sounds of nature are listed in the palace. The morning light shines on the clouds, and the prosperous world welcomes the sunrise.
2024-12-05

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