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Shengshi Tyco was rated as the most growing innovative pharmaceutical enterprise

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  • Time of issue:2022-08-09
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(Summary description)Today, there is good news from the 6th China Biomedical Innovation Cooperation Conference and the 2022 China biomedical industry value list award ceremony: Shengshi Tyco was selected into the list of "top 10 small molecule innovative drug enterprises with the most growth". In the past month, Shengshi Tyco has successively approved two new drug products under development by both China and the United States, opening a new journey for innovative drugs to go to sea.

Shengshi Tyco was rated as the most growing innovative pharmaceutical enterprise

(Summary description)Today, there is good news from the 6th China Biomedical Innovation Cooperation Conference and the 2022 China biomedical industry value list award ceremony: Shengshi Tyco was selected into the list of "top 10 small molecule innovative drug enterprises with the most growth". In the past month, Shengshi Tyco has successively approved two new drug products under development by both China and the United States, opening a new journey for innovative drugs to go to sea.

  • Categories:Company News
  • Author:
  • Origin:
  • Time of issue:2022-08-09
  • Views:0

Shengshi Tyco was rated as the most growing innovative pharmaceutical enterpriseToday, there is good news from the 6th China Biomedical Innovation Cooperation Conference and the 2022 China biomedical industry value list award ceremony: Shengshi Tyco was selected into the list of "top 10 small molecule innovative drug enterprises with the most growth". In the past month, Shengshi Tyco has successively approved two new drug products under development by both China and the United States, opening a new journey for innovative drugs to go to sea.


The current China Biomedical Innovation Cooperation Conference focuses on cutting-edge technology information, interprets the latest industrial policies, and links industry, University, research, and funding. Among them, Wanyi medicine and China Medical Research Institute made comprehensive judgments from multiple dimensions, such as strategic elements, product elements, competitive elements, team elements, commercialization elements and value elements, and conducted in-depth evaluation on industries, industries and enterprises. After collection, data return visit, systematic research and other evaluation processes, the "2022 China biomedical industry value list" was formed. The list was officially released at the plenary meeting.


Shengshi Tyco was founded in Suzhou Industrial Park in 2010. The core team has decades of experience in the whole life cycle of international drugs, and is committed to the R & D and industrialization of small molecule innovative drugs for breakthrough therapies. Relying on the integrated drug R & D technology platform and diversified business vision, the company has built a rich pipeline of innovative drugs, covering many disease fields such as glucose lowering, anticancer and rare diseases.

Recently, these three layout areas have achieved continuous success. In the field of glucose lowering, shenggliptin phosphate, an original new drug DPP-4 inhibitor, has entered the final stage of phase III clinical treatment, and is expected to fill the gap of domestic original oral glucose lowering drugs; Three of the anticancer drugs under research have entered the clinic. The FGFR / VEGFR dual target inhibitor cgt-6321 has been carried out in phase I clinical trials in advanced solid tumors, and this drug is expected to become a potential first in class drug; CXCR4 antagonist cgt-1881 is used for hematopoietic stem cell mobilization, and oral administration is more convenient; Cgt-9475, a new generation ALK / ret inhibitor, is expected to solve several major clinical pain points such as drug resistance and brain metastasis in the treatment of lung cancer. The first two projects have obtained the clinical license of the US FDA, which is a solid step for the company's innovative drugs to go to sea. In addition, the first domestic copy of the treatment of rare disease multiple sclerosis will be officially launched in the near future, which will benefit domestic patients with high quality and more affordable prices.

The

The world's first SGLT-2/DPP-4 dual target inhibitor with complementary advantages has been approved for clinical use

Recently, Shengshi Taike's Class 1 innovative drug SGLT-2/DPP-4 dual target inhibitor CGT-2201 has been granted implicit permission for clinical trials by the National Drug Administration. CGT-2201, which targets SGLT-2 and DPP-4, two important targets related to glucose metabolism, can be better used for the treatment of diabetes and its derivatives, including diabetes nephropathy and non-alcoholic fatty liver disease. In 2021, the number of diabetes patients in China will reach 141 million, ranking first in the world. Among the numerous patients with diabetes in China, 20-40% may suffer from complications of diabetes nephropathy. Among the existing hypoglycemic drugs, only sodium glucose cotransporter 2 (SGLT-2) inhibitor has significant renal protection effect in clinical verification, but its inherent reproductive and urinary system infection risks limit its use. Based on SGLT-2 inhibitors and combined with the characteristics of dipeptidyl peptidase 4 (DPP-4) inhibitors, we design and develop a drug that can improve blood sugar, reduce side effects of urinary and reproductive system infections, is not limited by renal function, and has kidney benefits. It is expected to fill the market gap and meet the needs of patients. Based on this market background and target characteristics, Shengshi Taike utilizes its own small molecule chimera drug technology platform to develop multi head multifunctional new drug products with synergistic mechanisms, with CGT-2201 being one of its representative works. It fuses the respective mechanism characteristics of SGLT-2 and DPP-4. On the basis of inhibiting the activity of SGLT-2 to reduce the reabsorption of glucose in the kidney, it also slows down the inactivation of DPP-4 on GLP-1, playing a dual role mechanism to play a superposition effect; While achieving considerable hypoglycemic effect, it can reduce the side effects of existing SGLT-2 drug urinary system infection; At the same time, without kidney excretion, it can reduce the burden of the kidney and reduce the contraindication of diabetes patients with renal insufficiency. Therefore, this drug will have the advantage of better controlling blood sugar and protecting patient kidney function. Shengshi Tyco was founded in Suzhou Industrial Park in 2010. Its core team has decades of experience in the whole life cycle of international drugs, and is committed to the R&D and industrialization of high-quality and differentiated small molecule innovative drugs. The company has built a product pipeline covering multiple disease fields such as hypoglycemic, anticancer, and autoimmune diseases with an integrated drug research and development technology platform and a diversified business perspective. In the field of hypoglycemic drugs, Shenggliptin, the core product independently developed by the company, has submitted an NDA (product launch application) to the National Drug Administration and has been accepted. The results of the Phase 3 clinical trial showed that low doses can reach the predetermined trial endpoint, while the high-dose group can also demonstrate the safety of the drug well. The therapeutic effect of "half the dose" is twice as effective, making it expected to become the best hypoglycemic drug in the class. At the same time, the company has also carried out a comprehensive layout around oral drugs and derivative diseases of various targets related to diabetes. CGT-2201, which was approved for clinical use this time, is one of its pipeline matrix members.
2023-04-20

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