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CGeneTech丨Make innovative drugs for the people with the mentality of the long march of thousands of miles

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  • Time of issue:2021-11-23
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(Summary description) On Nov. 21, Dr. Yu Qiang, the founder of CGeneTech and the president of SIP Talent Innovation and Entrepreneurship Promotion Association, successfully held the fourth stop of enterprise visit, which was guided by the Organization Department of SIP Industrial Committee, sponsored by SIP Enterprise Development Service Center and organized by SIP Talent Innovation and Entrepreneurship Promotion Association, and exchanged the "sweet and sour" of innovative drug field with more than 10 entrepreneurs and managers on site.

CGeneTech丨Make innovative drugs for the people with the mentality of the long march of thousands of miles

(Summary description) On Nov. 21, Dr. Yu Qiang, the founder of CGeneTech and the president of SIP Talent Innovation and Entrepreneurship Promotion Association, successfully held the fourth stop of enterprise visit, which was guided by the Organization Department of SIP Industrial Committee, sponsored by SIP Enterprise Development Service Center and organized by SIP Talent Innovation and Entrepreneurship Promotion Association, and exchanged the "sweet and sour" of innovative drug field with more than 10 entrepreneurs and managers on site.

  • Categories:Company News
  • Author:
  • Origin:
  • Time of issue:2021-11-23
  • Views:0

  On Nov. 21, Dr. Yu Qiang, the founder of CGeneTech and the president of SIP Talent Innovation and Entrepreneurship Promotion Association, successfully held the fourth stop of enterprise visit, which was guided by the Organization Department of SIP Industrial Committee, sponsored by SIP Enterprise Development Service Center and organized by SIP Talent Innovation and Entrepreneurship Promotion Association, and exchanged the "sweet and sour" of innovative drug field with more than 10 entrepreneurs and managers on site.

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  CGeneTech, which took root in Suzhou Industrial Park in 2010, is a biotech company dedicated to small molecule drug development in the fields of hypoglycemia, antitumor and rare diseases. At present, it has 6 clinical approvals and has applied for 30 invention patents. More than half of the 14 granted invention patents are global oriented, and Centec is on its way to the world based in China.

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  Since its inception, the company has built a rich pipeline of Class 1 innovative drugs, including the self-developed Shengliptin phosphate, a novel DPP-4 inhibitor, which is in Phase III clinical stage and is expected to complete Phase III clinical in mid-2022. This is just like the image metaphor often used by Dr. Yu Qiang, "Without climbing over snowy mountains and wading through grasslands, it is impossible to liberate the whole China". This is a sign that the first innovative drug of Shengshi Tai Ke will go to market for approval next year and reach the clinical efficacy endpoint. The approval of Shenggliptin phosphate will fill the gap of DPP-4 inhibitors in China (all the approved ones are imported for registration) and has a broad market prospect. When Dr. Yu Qiang modestly described this milestone as "the first step of a long march", the whole audience spontaneously applauded warmly, and colleagues in the industry deeply understood how much perseverance and hard work was behind this weighty phrase.

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  "The deadline of our project is always yesterday!" This "mantra" of CGeneTech shows the strict requirements of their project management, and the company has developed to a high level of talent stability, with no one above the director level jumping ship, which is rare in the background of the era of serious talent in-roll, and also reflects the cultural charm and endogenous power of this company from the side.

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  In the subsequent exchange, the participants had a lively discussion on industry trends, business models, innovation to the sea and other topics. Kui-Feng Wang, CEO of Qinhao Pharmaceuticals, Gao-Xi Jiang, CEO of Weinz Bio, and colleagues from Sequence Health Medical and Sensitive Microsystems threw out their insights and questions to deepen the links and expand the cooperation space in the exchange.

 (by "Suzhou Industrial Park Smart Talent")

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The world's first SGLT-2/DPP-4 dual target inhibitor with complementary advantages has been approved for clinical use

Recently, Shengshi Taike's Class 1 innovative drug SGLT-2/DPP-4 dual target inhibitor CGT-2201 has been granted implicit permission for clinical trials by the National Drug Administration. CGT-2201, which targets SGLT-2 and DPP-4, two important targets related to glucose metabolism, can be better used for the treatment of diabetes and its derivatives, including diabetes nephropathy and non-alcoholic fatty liver disease. In 2021, the number of diabetes patients in China will reach 141 million, ranking first in the world. Among the numerous patients with diabetes in China, 20-40% may suffer from complications of diabetes nephropathy. Among the existing hypoglycemic drugs, only sodium glucose cotransporter 2 (SGLT-2) inhibitor has significant renal protection effect in clinical verification, but its inherent reproductive and urinary system infection risks limit its use. Based on SGLT-2 inhibitors and combined with the characteristics of dipeptidyl peptidase 4 (DPP-4) inhibitors, we design and develop a drug that can improve blood sugar, reduce side effects of urinary and reproductive system infections, is not limited by renal function, and has kidney benefits. It is expected to fill the market gap and meet the needs of patients. Based on this market background and target characteristics, Shengshi Taike utilizes its own small molecule chimera drug technology platform to develop multi head multifunctional new drug products with synergistic mechanisms, with CGT-2201 being one of its representative works. It fuses the respective mechanism characteristics of SGLT-2 and DPP-4. On the basis of inhibiting the activity of SGLT-2 to reduce the reabsorption of glucose in the kidney, it also slows down the inactivation of DPP-4 on GLP-1, playing a dual role mechanism to play a superposition effect; While achieving considerable hypoglycemic effect, it can reduce the side effects of existing SGLT-2 drug urinary system infection; At the same time, without kidney excretion, it can reduce the burden of the kidney and reduce the contraindication of diabetes patients with renal insufficiency. Therefore, this drug will have the advantage of better controlling blood sugar and protecting patient kidney function. Shengshi Tyco was founded in Suzhou Industrial Park in 2010. Its core team has decades of experience in the whole life cycle of international drugs, and is committed to the R&D and industrialization of high-quality and differentiated small molecule innovative drugs. The company has built a product pipeline covering multiple disease fields such as hypoglycemic, anticancer, and autoimmune diseases with an integrated drug research and development technology platform and a diversified business perspective. In the field of hypoglycemic drugs, Shenggliptin, the core product independently developed by the company, has submitted an NDA (product launch application) to the National Drug Administration and has been accepted. The results of the Phase 3 clinical trial showed that low doses can reach the predetermined trial endpoint, while the high-dose group can also demonstrate the safety of the drug well. The therapeutic effect of "half the dose" is twice as effective, making it expected to become the best hypoglycemic drug in the class. At the same time, the company has also carried out a comprehensive layout around oral drugs and derivative diseases of various targets related to diabetes. CGT-2201, which was approved for clinical use this time, is one of its pipeline matrix members.
2023-04-20

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