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Good news! Dr. Tong Wang, CSO of Centec and Dr. Jiahong Zhao, CMO of Centec were awarded as Gusu Leading Talents

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  • Time of issue:2021-12-24
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(Summary description)Suzhou, China, December 23, 2021 - Dr. Tong Wang, CSO (Chief Scientific Officer) and Dr. Jiahong Zhao, CMO (Chief Medical Officer) of CGeneTech have been selected as the second batch of Gusu Leaders in Suzhou City for the year 2021.

Good news! Dr. Tong Wang, CSO of Centec and Dr. Jiahong Zhao, CMO of Centec were awarded as Gusu Leading Talents

(Summary description)Suzhou, China, December 23, 2021 - Dr. Tong Wang, CSO (Chief Scientific Officer) and Dr. Jiahong Zhao, CMO (Chief Medical Officer) of CGeneTech have been selected as the second batch of Gusu Leaders in Suzhou City for the year 2021.

  • Categories:Company News
  • Author:
  • Origin:
  • Time of issue:2021-12-24
  • Views:0

Suzhou, China, December 23, 2021 - Dr. Tong Wang, CSO (Chief Scientific Officer) and Dr. Jiahong Zhao, CMO (Chief Medical Officer) of CGeneTech have been selected as the second batch of Gusu Leaders in Suzhou City for the year 2021.

Dr. Tong Wang received his bachelor's degree in chemistry from Peking University and his PhD in chemistry from Syracuse University. Dr. Wang has more than 20 years of experience in full chain drug development and management in top pharmaceutical companies and research institutes in the US. Prior to joining CGeneTech, Dr. Wang worked at Schering-Plough and Translational Genomics Institute/Translational Drug Development, where he led nearly ten world-first small molecule drug development projects in the medical fields of cancer, immunology, ophthalmology and metabolism, and successfully advanced four new drug projects to the clinical stage.

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Dr. Tong Wang, CSO (Chief Scientific Officer) of CGeneTech

Dr. Tong Wang has been awarded the Suzhou Park Innovation and Technology Leader A Class Talent, High-end Foreign Expert Introduction Program, and Senior Engineer, and has obtained nearly 20 invention patents and published more than 10 academic papers.

Dr. Jiahong Zhao is a medical doctor from Fudan University School of Medicine, with more than 20 years of professional and team management experience in drug clinical trials, 6 years of work experience as a hematologist in clinical internal medicine and teaching experience in medical school. Before joining CGeneTech, he worked as Vice President and CMO of a large CRO company, responsible for more than 600 clinical practical projects, presided over the clinical development of 3 new varieties of blood products successfully marketed, wrote 7 varieties of drug instructions selected by the State Pharmacopoeia Commission, which became the standard version of the blood products industry and used to date, participated in the State Drug Administration and CDE organization as an external expert As an external expert, he participated in the "7.22 data verification work" and the drafting and revision of many technical guidelines organized by the State Drug Administration and CDE.

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Dr. Jiahong Zhao, CMO (Chief Medical Officer) of CGeneTech

Dr. Jiahong Zhao has been awarded more than ten honorary titles such as special professor of Jiangsu University and Zhejiang University of Traditional Chinese Medicine, external reviewer of CDE Professional Committee on Blood Products, special editorial board member and reviewer of Zhongnan Pharmacology, member of Professional Committee on Research and Evaluation of Traditional Chinese Medicine Injectables, reviewer of pharmaceutical projects of Ministry of Science and Technology of China, Shanghai Science and Technology Commission and Shanghai Health and Health Commission.

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The world's first SGLT-2/DPP-4 dual target inhibitor with complementary advantages has been approved for clinical use

Recently, Shengshi Taike's Class 1 innovative drug SGLT-2/DPP-4 dual target inhibitor CGT-2201 has been granted implicit permission for clinical trials by the National Drug Administration. CGT-2201, which targets SGLT-2 and DPP-4, two important targets related to glucose metabolism, can be better used for the treatment of diabetes and its derivatives, including diabetes nephropathy and non-alcoholic fatty liver disease. In 2021, the number of diabetes patients in China will reach 141 million, ranking first in the world. Among the numerous patients with diabetes in China, 20-40% may suffer from complications of diabetes nephropathy. Among the existing hypoglycemic drugs, only sodium glucose cotransporter 2 (SGLT-2) inhibitor has significant renal protection effect in clinical verification, but its inherent reproductive and urinary system infection risks limit its use. Based on SGLT-2 inhibitors and combined with the characteristics of dipeptidyl peptidase 4 (DPP-4) inhibitors, we design and develop a drug that can improve blood sugar, reduce side effects of urinary and reproductive system infections, is not limited by renal function, and has kidney benefits. It is expected to fill the market gap and meet the needs of patients. Based on this market background and target characteristics, Shengshi Taike utilizes its own small molecule chimera drug technology platform to develop multi head multifunctional new drug products with synergistic mechanisms, with CGT-2201 being one of its representative works. It fuses the respective mechanism characteristics of SGLT-2 and DPP-4. On the basis of inhibiting the activity of SGLT-2 to reduce the reabsorption of glucose in the kidney, it also slows down the inactivation of DPP-4 on GLP-1, playing a dual role mechanism to play a superposition effect; While achieving considerable hypoglycemic effect, it can reduce the side effects of existing SGLT-2 drug urinary system infection; At the same time, without kidney excretion, it can reduce the burden of the kidney and reduce the contraindication of diabetes patients with renal insufficiency. Therefore, this drug will have the advantage of better controlling blood sugar and protecting patient kidney function. Shengshi Tyco was founded in Suzhou Industrial Park in 2010. Its core team has decades of experience in the whole life cycle of international drugs, and is committed to the R&D and industrialization of high-quality and differentiated small molecule innovative drugs. The company has built a product pipeline covering multiple disease fields such as hypoglycemic, anticancer, and autoimmune diseases with an integrated drug research and development technology platform and a diversified business perspective. In the field of hypoglycemic drugs, Shenggliptin, the core product independently developed by the company, has submitted an NDA (product launch application) to the National Drug Administration and has been accepted. The results of the Phase 3 clinical trial showed that low doses can reach the predetermined trial endpoint, while the high-dose group can also demonstrate the safety of the drug well. The therapeutic effect of "half the dose" is twice as effective, making it expected to become the best hypoglycemic drug in the class. At the same time, the company has also carried out a comprehensive layout around oral drugs and derivative diseases of various targets related to diabetes. CGT-2201, which was approved for clinical use this time, is one of its pipeline matrix members.
2023-04-20

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