The two backbones of CGeneTech won new honors in the third Jinji Lake skill Invitational Competition

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Time of issue:2022-02-22
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(Summary description)During the anti epidemic campaign in Suzhou, we can see that medical work is inseparable from excellent analytical and technical personnel. Recently, good news came from the 11th high skill competition and the 3rd Jinjihu skill Invitational Competition: two technical backbones of CGeneTech's new drug R & D - Analysis Department passed all the way and won the second prize in the final of biochemical pharmaceutical engineering technology (staff group) team competition.

The two backbones of CGeneTech won new honors in the third Jinji Lake skill Invitational Competition

(Summary description)During the anti epidemic campaign in Suzhou, we can see that medical work is inseparable from excellent analytical and technical personnel. Recently, good news came from the 11th high skill competition and the 3rd Jinjihu skill Invitational Competition: two technical backbones of CGeneTech's new drug R & D - Analysis Department passed all the way and won the second prize in the final of biochemical pharmaceutical engineering technology (staff group) team competition.

Categories:Company News
Author:
Origin:
Time of issue:2022-02-22
Views:0

During the anti epidemic campaign in Suzhou, we can see that medical work is inseparable from excellent analytical and technical personnel. Recently, good news came from the 11th high skill competition and the 3rd Jinjihu skill Invitational Competition: two technical backbones of CGeneTech's new drug R & D - Analysis Department passed all the way and won the second prize in the final of biochemical pharmaceutical engineering technology (staff group) team competition.

In 2021, the 11th high skill competition and the 3rd Jinji Lake skill Invitational Competition opened 22 events with the theme of "technology inherits ingenuity and creates the future". The competition closely follows the demand for skilled talents in the development of key industries and emerging industries in the park. Since its launch, it has attracted more than 6600 players, and finally 2927 people entered the finals.

High quality talent reserve is a necessary factor for enterprise innovation. Two key employees of Shengshi Tyco's new drug R & D - Analysis Department participated in the third Jinji Lake skill Invitational Competition - "Baituo Agilent Cup" biomedical chromatographic analysis technology national open challenge. After fierce competition in the preliminary and final, they finally won the second prize in the final of biochemical pharmaceutical engineering technology (staff group) team competition.

Founded in Suzhou Industrial Park in 2010, CGeneTech is a biotechnology company committed to the research and development of small molecule drugs in the fields of hypoglycemic, antitumor and rare diseases.
Since its establishment, the company has built a rich pipeline of class 1 innovative drugs. Its self-developed shenggliptin phosphate is a new DPP-4 inhibitor, which is in phase 3 clinical practice. It is expected that all subjects will complete phase 3 clinical practice in the middle of 2022. From the results of the subjects who completed the trial, shenggliptin phosphate showed good safety and the effect of reducing glycosylated hemoglobin. If it reaches the end point of clinical efficacy, its approval will fill the gap of domestic production of DPP-4 inhibitors (now approved are imported and registered), and has broad market prospects.

Not long ago, CGeneTech generic telifloxamine tablets were officially approved in China. The approved indication is recurrent multiple sclerosis, which is the first domestic telifloxamine approved for listing in China. After listing, it will bring high-quality and more accessible therapeutic drugs to domestic patients.

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Previous: Shengshi Tyco was rated as the most growing innovative pharmaceutical enterprise

Next: Good news! Dr. Tong Wang, CSO of Centec and Dr. Jiahong Zhao, CMO of Centec were awarded as Gusu Leading Talents

New generation of highly selective DPP-4 inhibitors international diabetes expert Professor Ji Linong interprets Shengglitin Phase III clinical data

2023-05-31

The world's first SGLT-2/DPP-4 dual target inhibitor with complementary advantages has been approved for clinical use

Recently, Shengshi Taike's Class 1 innovative drug SGLT-2/DPP-4 dual target inhibitor CGT-2201 has been granted implicit permission for clinical trials by the National Drug Administration. CGT-2201, which targets SGLT-2 and DPP-4, two important targets related to glucose metabolism, can be better used for the treatment of diabetes and its derivatives, including diabetes nephropathy and non-alcoholic fatty liver disease. In 2021, the number of diabetes patients in China will reach 141 million, ranking first in the world. Among the numerous patients with diabetes in China, 20-40% may suffer from complications of diabetes nephropathy. Among the existing hypoglycemic drugs, only sodium glucose cotransporter 2 (SGLT-2) inhibitor has significant renal protection effect in clinical verification, but its inherent reproductive and urinary system infection risks limit its use. Based on SGLT-2 inhibitors and combined with the characteristics of dipeptidyl peptidase 4 (DPP-4) inhibitors, we design and develop a drug that can improve blood sugar, reduce side effects of urinary and reproductive system infections, is not limited by renal function, and has kidney benefits. It is expected to fill the market gap and meet the needs of patients. Based on this market background and target characteristics, Shengshi Taike utilizes its own small molecule chimera drug technology platform to develop multi head multifunctional new drug products with synergistic mechanisms, with CGT-2201 being one of its representative works. It fuses the respective mechanism characteristics of SGLT-2 and DPP-4. On the basis of inhibiting the activity of SGLT-2 to reduce the reabsorption of glucose in the kidney, it also slows down the inactivation of DPP-4 on GLP-1, playing a dual role mechanism to play a superposition effect; While achieving considerable hypoglycemic effect, it can reduce the side effects of existing SGLT-2 drug urinary system infection; At the same time, without kidney excretion, it can reduce the burden of the kidney and reduce the contraindication of diabetes patients with renal insufficiency. Therefore, this drug will have the advantage of better controlling blood sugar and protecting patient kidney function. Shengshi Tyco was founded in Suzhou Industrial Park in 2010. Its core team has decades of experience in the whole life cycle of international drugs, and is committed to the R&D and industrialization of high-quality and differentiated small molecule innovative drugs. The company has built a product pipeline covering multiple disease fields such as hypoglycemic, anticancer, and autoimmune diseases with an integrated drug research and development technology platform and a diversified business perspective. In the field of hypoglycemic drugs, Shenggliptin, the core product independently developed by the company, has submitted an NDA (product launch application) to the National Drug Administration and has been accepted. The results of the Phase 3 clinical trial showed that low doses can reach the predetermined trial endpoint, while the high-dose group can also demonstrate the safety of the drug well. The therapeutic effect of "half the dose" is twice as effective, making it expected to become the best hypoglycemic drug in the class. At the same time, the company has also carried out a comprehensive layout around oral drugs and derivative diseases of various targets related to diabetes. CGT-2201, which was approved for clinical use this time, is one of its pipeline matrix members.

2023-04-20